Fig. 3.

CN54gp140 antigen-specific antibody serum responses to 500 μg vaccine antigen in the presence of 500 μg R848 adjuvant per vaginal ring. IM Primed – animals received an IM prime at day 0 then three vaginal ring placements, each retained in situ for 7 days, at monthly intervals. Unprimed – animals received the vaginal rings without a prior IM vaccination. The shaded areas indicate the 7-day periods during which a ring device was present in the sheep vagina. (A) Vaccine antigen-specific IgG and (B) IgA responses. Data compared with a Mann-Whitney test (n = 5 per group).