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Comparison with gold standard FcR affinity characterization by SPR.
Comparison of previously determined ELISA/SPR binding affinities (Moldt et al., 2011) of a panel of mAb Fc mutants against Fc Array MFI. A) Anti-huIgG-PE detection of Fc variants bound to gp120-conjugated beads. B) FcγRIII detection of Fc variants bound to gp120 beads. C-E) Correlations between ELISA and Fc Array (C), SPR and Fc Array (D), and ELISA and SPR (E) for the panel of Fc mutants.
