Table 4. Haplotype analysis of SNPs rs7903146 and rs114770437 in TCF7L2.
rs7903146 allele | rs114770437 allele | Haplotype frequency (%) | OR (95% CI) | P-value | |
---|---|---|---|---|---|
Cases (n = 2632) | Controls (n = 2596) | ||||
C | G | 62.3 | 64.1 | 1.00 (reference) | reference |
T | G | 31.7 | 28.1 | 1.18 (1.09, 1.29) | 5.7 x 10−5 |
C | A | 6.0 | 7.8 | 0.77 (0.66, 0.90) | 1.3 x 10−3 |
Abbreviations: OR, odds ratio (adjusted for age at baseline, geographical region, genotyping batch, and genotype principal components); CI, confidence interval.