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. 2017 Mar 2;12(3):e0172882. doi: 10.1371/journal.pone.0172882

Table 1. Antimicrobial susceptibility and classification of P.aeruginosa strains as PDR, XDR, MDR or S.

P ID Y R S O ST Antibiotics tested RP
1 2 3 4 5 6 7 8 9
GEN TOB AK IMI MEM CAZ CPM CIP LEV CB P/T AZT FOS CS
1 HIM1 2007 S B ↑ 1723 R ND R R R R R R ND > 128 R R > 128 I XDR
2 HIM2/1 2007 STx C † 1724 ND ND R R R R R R ND > 128 I R > 128 S XDR
HIM3 1725 R ND ND I
3 HIM3/1 2007 E U ↑ 1725 R ND R R R R R R ND > 128 R R > 128 I XDR
4 HIM3/2 2007 STx U ↑ 1725 R ND R R R R R R ND > 128 I R > 128 I XDR
5 HIM3/3 2007 N C ↑ 1725 ND ND R ND R ND R R ND > 128 R R > 128 I XDR
HIM3/4
6 HIM3/5 2007 PICU U ↑ 1725 R ND R R R R R R ND > 128 I R > 128 I XDR
7 HIM2 2008 S B ↑ 1724 R R R R R R R R R > 128 I R > 128 I XDR
8 HIM3/6 2008 P U ↑ 1725 R R R R R R R R R > 128 R R > 128 I XDR
9 HIM3/7 2008 S U ↑ 1725 R R R R R R R R R > 128 R R > 128 I XDR
10 HIM3/11 2008 E U † 1725 ND ND I ND R ND R R ND > 128 I R > 128 S MDR
HIM3/12 R R R R R R R R R > 128 I R > 128 S XDR
11 HIM3/13 2008 Neph U ↑ 1725 R R R R R R R R R > 128 R R > 128 I XDR
12 HIM3/14 2008 E U ↑ 1725 R R R R R R R R S > 128 R R > 128 I XDR
13 HIM3/15 2008 S U ↑ 1725 R R R R R R R R R > 128 R R > 128 I XDR
14 HIM3/26 2008 Neph U ↑ 1725 S S S S S S S S S > 128 I R > 128 S MDR
15 HIM4 2008 PICU B † 1726 R R R R R R R R R > 128 R R > 128 S XDR
16 HIM9 2008 E B ↑ 1731 S S S S S S I S I > 128 S S > 128 S S
17 HIM10 2008 PICU B † 2226 S S S S S S S S S > 128 S S 128 S S
18 HIM11 2008 NICU B ? 1733 S S S S R S S S S > 128 S S > 128 I S
19 HIM12 2008 P B ↑ 1734 S S S S S S S S S 128 S S > 128 I S
20 HIM13 2008 O B † 1737 S S S S S S S S S 64 S S > 128 I S
21 HIM14 2008 P U ↑ 1735 S S S S S S S S S 64 S S > 128 I S
22 HIM5 2008 P B ? 1727 R S R R R R R R I > 128 R R > 128 I XDR
HIM6 1728 ND ND ND ND ND I S
23 HIM16 2008 Neph U ↑ 1736 S S S S S S S S S 128 S I > 128 I S
HIM16/1 P I 32 S
P ID Y R S O ST Antibiotics tested RP
1 2 3 4 5 6 7 8 9
GEN TOB AK IMI MEM CAZ CPM CIP LEV CB P/T AZT FOS CS
24 HIM7 2009 PICU B † 1729 R R R R R R R R R > 128 R S 64 I XDR
25 HIM3/8 2008 S U ↑ 1725 ND ND R ND R ND R R ND > 128 R R > 128 I XDR
HIM3/9 Neph
HIM3/10 2010 STx 1730 R R R R R
HIM8 Neph
26 HIM15 2008 E B † 561 S S S S S S S S S > 128 S S > 128 I S
HIM3/20 2010 0 U 1725 R R R R R R R R R R R XDR
27 HIM3/18 2010 STx U ↑ 1725 R R R R R R R R R > 128 R R > 128 I XDR
HIM3/19 ND ND ND ND ND
28 HIM3/16 2010 Neph U ↑ 1725 R R R R R R R R R > 128 R R > 128 S XDR
29 HIM3/17 2010 STx U ↑ 1725 R R R R R R R R R > 128 R R > 128 S XDR
30 HIM3/21 2010 Neph C ↑ 1725 R R R ND R R R R R > 128 R R > 128 I XDR
31 HIM3/22 2010 STx B ↑ 1725 R R R R R I R S S > 128 R R > 128 I S
HIM3/23 U R R R S
32 HIM3/24 2010 ITx U ↑ 1725 R R R R R R R R R > 128 R R > 128 I XDR
HIM3/25
33 HIM20 2011 Neph M ? 2246 R R R R R R R R R > 128 I R > 128 I XDR
34 HIM17 2012 N U ↑ 2243 R R R R R R R R R > 128 R R > 128 I XDR
35 HIM18 2012 O U ↑ 2244 R R S R R R R R R > 128 R R > 128 I XDR
36 HIM19 2012 ITx U ? 2245 R R R R R R R R R > 128 I R > 128 I XDR
37 HIM3/27 2012 E U ↑ 1725 R R R R R R R R R > 128 R R > 128 I XDR
38 HIM3/28 2012 Neph U ↑ 1725 R R R R R R R R R > 128 I R > 128 R XDR
39 HIM3/29 2013 E U ↑ 1725 R R R R R R R R R > 128 R R > 128 R PDR
40 HIM3/30 2013 Neph U ? 1725 R R R R R R R R R > 128 R R > 128 I XDR
41 HIM3/31 2013 Neph U ? 1725 R R R R R R R R R > 128 R R > 128 I XDR
42 HIM3/32 2013 C U ? 1725 R R R R R R R R R > 128 R R > 128 R PDR
43 HIM22 2013 C M † 2248 R R S R R R R S R > 128 I R > 128 S MDR
44 233 2013 E U ? 233 R R R R R R R R R > 128 R S 64 R XDR
45 233/1 2013 Neph U ? 233 R R R R R R R R R > 128 R S > 128 I XDR
46 112 2013 Imed U ? 112 R R R I R R R S S > 128 S S > 128 R MDR

P: Patient; ID: Assigned in the MLST P. aeruginosa database; Y: Year; R: Room; S: Source; O: Outcome; ↑: Discharged; †: Dead;?: Unknown; ST: Sequence Type; B: Blood; C: Catheter; U: Urine; M: Miscellaneous; S: Surgery; STx: Surgical Therapy; E: Emergency Room; N: Neurology; PICU: Pediatric Intensive Care Unit; P: Pediatrics; Neph: Nephrology; ITx: Internal Therapy; O: Oncology; C: Cardiology; NICU: Neonatal Intensive Care Unit; IMed: Internal Medicine; Antibiotics tested: Aminoglycosides: Gentamicin (GEN), Tobramycin (TOB), Amikacin (AK); Carbapenems: Imipenem (IMI), Meropenem (MEM); Cephalosporins: Ceftazidime (CAZ), Cefepime (CPM); Fluoroquinolones: Ciprofloxacin (CIP), Levofloxacin (LEV); Penicillins: Carbenicilin (CB); Penicillins + β-lactamase inhibitors: Piperacillin/Tazobactam (P/T); Monobactams: Aztreonam (AZT); Phosphonic acids: Fosfomycin (FOS); Polymyxins: Colistin (CS). (CLSI, 2016) [18]

PDR: Pan Drug Resistant. XDR: Extensively Drug Resistant. MDR: Multi Drug Resistant. S: Sensitive. Reference strains: P. aeruginosa ATCC® 27853 and Escherichia coli ATCC® 25922.

Discharge/d patients: 60.87%. Mortality rate: 17.39%. Unknown patient outcome: 21.74%.