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. 2017 Jan 23;8:6. doi: 10.3389/fimmu.2017.00006

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Copyright © 2017 Carlini, Picard, Garulli, Piquemal, Roubertoux, Chiaroni, Chanez, Gras and Di Cristofaro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptional expression analyzed by Q-PCR of cumulated HLA-G1/-G4/-G5, HLA-G1/-G5, and pan HLA-G Ex5–6 in human bronchial epithelium cells (HBEC) on day 21. Fold change compared to JEG-3 in HBEC from healthy controls (HC) [0.156 (0.03–0.92)], patients with mild asthma (MA) [0.03 (0.0008–0.19)], and patients with severe asthma (SA) [0.06 (0.001–0.13)]. Kruskal–Wallis ANOVA performed on three modalities: p = 0.047. HC showed a significantly higher expression of cumulated pan-G1-G4-G5 than both MA and SA (p < 0.001 and p < 0.05, respectively; Mann–Whitney test).