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. 2017 Jan 23;8:6. doi: 10.3389/fimmu.2017.00006

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Copyright © 2017 Carlini, Picard, Garulli, Piquemal, Roubertoux, Chiaroni, Chanez, Gras and Di Cristofaro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptional expression analyzed by Q-PCR of HLA-G1/G5 and HLA-G2/G6 in healthy controls (HC), patients with mild asthma (MA), and patients with severe asthma (SA). Expression fold change during human bronchial epithelium cells re-differentiation is compared to D0. HLA-G1/-G5 expression is significantly higher at D0 for HC and MA, but not for SA (Kruskal–Wallis ANOVA: p = 0.033, p = 0.013, and p = 0.425, respectively). HLA-G2/-G6 expression was significantly lower at D0 for HC, MA, and SA (Kruskal–Wallis ANOVA: HC, MA, and SA p < 0.0001).