Table 2. Associations between osteoprotegerin (OPG) and measurements of myocardial injury and function.
| Before PCI | P-value | After PCI | P-value | Day 1 | P-value | 4 months | P-value | |
|---|---|---|---|---|---|---|---|---|
| CMRa in acute phase | n = 226 | n = 229 | n = 225 | n = 228 | ||||
| Time to CMR (days) | 0.08 | 0.26 | 0.14 | 0.03 | 0.07 | 0.33 | 0.13 | 0.05 |
| Infarct size (% of LVb mass) | 0.10 | 0.15 | 0.08 | 0.26 | 0.26 | <0.001 | 0.04 | 0.61 |
| Ejection fraction (%) | -0.11 | 0.09 | -0.10 | 0.15 | -0.30 | <0.001 | -0.08 | 0.26 |
| Area at risk (% of LV) | 0.05 | 0.47 | 0.10 | 0.15 | 0.25 | 0.001 | 0.05 | 0.48 |
| Presence of MVOc | 0.11 | 0.12 | 0.07 | 0.29 | 0.20 | 0.003 | 0.08 | 0.24 |
| CMR after 4 months | n = 236 | n = 238 | n = 233 | n = 246 | ||||
| Time to CMR (months) | -0.02 | 0.80 | -0.13 | 0.05 | -0.12 | 0.08 | 0.01 | 0.92 |
| Infarct size (% of LV mass) | 0.05 | 0.45 | 0.03 | 0.67 | 0.23 | <0.001 | 0.07 | 0.28 |
| Ejection fraction (%) | -0.09 | 0.19 | -0.12 | 0.06 | -0.26 | <0.001 | -0.05 | 0.42 |
| Myocardial Salvage (%) | -0.07 | 0.32 | -0.01 | 0.90 | -0.07 | 0.36 | -0.04 | 0.59 |
| Delta EDVd (ml) | 0.02 | 0.77 | 0.12 | 0.09 | 0.85 | 0.22 | -0.03 | 0.66 |
Data are presented as Spearman correlation coefficients with p-values. Significant p-values are highlighted in bold. OPG was measured before and immediately after the PCI-procedure, at Day 1 (median 14.7 hours after PCI) and at 4-month follow-up.
aCMR: cardiac magnetic resonance imaging
bLV: left ventricle
cMVO: microvascular obstruction
dEDV: end-diastolic volume of LV.