Table 5. Univariable and multivariable linear regression analyses of the associations between osteoprotegerin (OPG) measured at Day 1 and final infarct size and left ventricular ejection fraction measured by CMR at 4 months.

Adjusted for clinical and biochemical covariates.

	Final infarct size			LVEF
	Univariable analysis
Variable	β	95% CI	p-value	β	95% CI	p-value
OPGa (log)	15.2	6.6, 23.7	0.001	-18.3	-26.9, -9.7	<0.001
	Multivariable analysis
	Model 1
OPG (log)	11.9	4.1, 19.7	<0.001	-18.9	-27.3, -10.4	<0.001
Age				0.1	-0.01, 0.3	0.08
Male sex	3.6	0.1, 7.2	0.04	-5.7	-9.4, -2.0	0.03
Time from symptom to PCIb (log)	10.2	3.3, 17.1	0.004	-9.5	-16.6, -2.3	0.01
Anterior MIc	9.6	6.9, 12.3	<0.001	-7.2	-10.0, -4.3	<0.001
	Multivariable analysis
	Model 2
OPG (log)	1.9	-3.7, 7.6	0.49	-9.0	-16.2, -1.9	0.01
Age				0.1	-0.01, 0.2	0.08
Male sex
Time from symptom to PCI (log)
Anterior MI	4.4	2.4, 6.4	<0.001	-2.9	-5.4, -0.5	0.02
Peak troponin T (log)	22.6	19.8, 25.4	<0.001	-19.3	-22.7, -15.8	<0.001
	Multivariable analysis
	Model 3
OPG (log)	0.5	-5.3, 6.3	0.87	-4.9	-12.1, -2.2	0.17
Age
Male sex
Time from symptom to PCI (log)
Anterior MI	4.2	2.1, 6.2	<0.001	-2.6	-5.1, -0.1	0.05
Peak troponin T (log)	21.3	18.2, 24.4	<0.001	-17.7	-21.4, -13.9	<0.001
Peak CRPd (log)	2.1	0.02, 4.1	0.06	-3.1	-5.7, -0.5	0.02
NT-proBNPe (log)	0.01	-1.9, 1.9	0.99	0.3	-2.1, 2.6	0.83

Model 1: OPG, age, male sex, time from symptom to PCI, anterior MI. Model 2: model 1 + peak troponin t. Model 3: Model 1 + peak troponin T + peak CRP + NT-proBNP. β: unstandardized β

^aOPG: Osteoprotegerin measured median 14.7 hours after PCI

^bPCI: Percutaneous coronary intervention

^cInfarct localization – Anterior myocardial infarction (MI) vs inferior or posterior MI

^dCRP: C-reactive protein

^eNT-proBNP: N-terminal pro-B-type natriuretic peptide. Significant p-values are highlighted in bold.