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. 2017 Mar 2;12(3):e0173335. doi: 10.1371/journal.pone.0173335

Fig 4. Metformin inhibits the expression of cell proliferating regulators, Erk and Akt.

Fig 4

A-B: Representative immunoblot of three different experiments of pho-Erk (A) and pho-Akt protein levels (B) in BPH-1 cells 48h after treatment of metformin. C-D: Quantification of the immunoblot protein levels of pho-Erk (C) and pho-Akt (D) in BPH-1 cells treated with 5 mM metformin for 48 hours by normalization to GAPDH and Akt, respectively. *, P<0.05, compared with control group. CTR: control, Met: metformin.