. 2017 Mar 2;13(3):e1006177. doi: 10.1371/journal.ppat.1006177

Table 1. Role of Nod2 in the host response toward pathogenic bacteria.

Bacteria	Bacterial susceptibility in Nod2^KO	Intestinal inflammation in Nod2^KO	Cytokines/ chemokines in Nod2^KO	Intestinal permeability	Nod2 and TLR synergy	RIP2 mediated	Activation of Caspase-1 and IL-1β	Refs
Yersinia pseudotuberculosis, Y. enterocolitica	Decreased	Exacerbated	IL-1β decreased	Increased in WT mice. Unchanged in Nod2^KO mice.	Yes (TLR2)	Yes	Yes	[39,87,88]
Yersinia pseudotuberculosis, Y. enterocolitica	Decreased	Exacerbated	IL-1β decreased		Yes (TLR2)	Yes	Yes	[39,87,88]
Listeria monocytogenes	Increased	Not studied	IL-6, IL-12 & TNF-α decreased	Increased in WT mice. Not studied in Nod2^KO mice.	Not studied	Yes	Not studied	[29,98]
Pseudomonas fluorescens	Decreased	Absent	IL-1β & TNF-α decreased	Increased in WT mice. Unchanged in Nod2^KO mice.	Not studied	Yes	Yes	[105,108]
E. coli	Increased (attachment to M-cells enhanced)	Absent	TNF-α decreased	Increased in WT mice.	Not studied	Not studied	Not studied	[65,122]
Citrobacter rodentium	Increased	Reduced at day 12 Increased at day 22	IFN-γ, IL-17 α CCL2 decreased	Not studied	Not studied	Yes	Not studied	[123, 124, 125]
Campylobacter jejuni	Unchanged in Nod2^KO mice. Increased in IL10/Nod2^KO mice	Absent in Nod2^KO mice. Exacerbated in IL10/Nod2^KO mice.	Unchanged in Nod2^KO mice. IL-1β, TNF-α & CxCL1 decreased in IL10/Nod2^KO mice.	Not studied	Not studied	Not studied	Yes	[135,136]
Heliobacter hepaticus	Increased	Exacerbated	IFN-γ increased	Not studied	Not studied	Yes	Not studied	[72,110]