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. Author manuscript; available in PMC: 2017 Mar 2.
Published in final edited form as: JAMA Psychiatry. 2016 Feb;73(2):150–158. doi: 10.1001/jamapsychiatry.2015.2688

Table 2.

Bivariate Associations Between DSM-IV Mental Disorders and the Subsequent Onset or Diagnosis of Chronic Physical Conditions

Mental Disordera Chronic Physical Condition, OR (95% CI)
Arthritis Any Chronic
Painb
Heart Disease Stroke Hypertension Diabetes
Mellitus
Asthma Chronic
Lung Disease
Peptic Ulcer Cancer
Mood disorder
  Major depressive
episode/dysthymia
1.6 (1.5–1.8)c 1.7 (1.6–1.8)c 1.5 (1.3–1.8)c 1.6 (1.3–2.1)c 1.4 (1.2–1.5)c 1.4 (1.2–1.6)c 1.5 (1.3–1.8)c 2.1 (1.6–2.8)c 1.7 (1.5–1.9)c 1.2 (1.0–1.5)c
  Bipolar disorder (broad) 1.7 (1.4–2.0)c 1.8 (1.6–2.1)c 1.6 (1.1–2.4)c 1.9 (1.1–3.1)c 1.4 (1.1–1.8)c 1.7 (1.2–2.3)c 2.4 (1.7–3.3)c 2.3 (1.5–3.7)c 1.8 (1.4–2.3)c 1.5 (1.0–2.2)
Anxiety disorder
  Panic disorder 1.5 (1.3–1.8)c 1.9 (1.6–2.1)c 2.1 (1.6–2.7)c 1.9 (1.1–3.1)c 1.7 (1.4–2.0)c 1.8 (1.3–2.4)c 1.9 (1.3–2.7)c 2.2 (1.4–3.3)c 1.9 (1.4–2.4)c 1.6 (1.2–2.1)c
  Generalized anxiety disorder 1.8 (1.6–2.0)c 1.9 (1.8–2.2)c 1.4 (1.1–1.7)c 1.5 (1.0–2.3)c 1.4 (1.2–1.5)c 1.3 (1.0–1.6)c 1.7 (1.4–2.2)c 2.5 (1.8–3.5)c 1.5 (1.3–1.8)c 1.0 (0.8–1.3)
  Social phobia 1.5 (1.4–1.7)c 1.8 (1.7–2.0)c 1.5 (1.2–1.9)c 1.8 (1.3–2.5)c 1.5 (1.3–1.6)c 1.3 (1.1–1.6)c 1.4 (1.1–1.7)c 1.9 (1.4–2.6)c 1.8 (1.6–2.2)c 1.1 (0.9–1.3)c
  Specific phobia 1.5 (1.4–1.7)c 1.8 (1.7–1.9)c 1.8 (1.5–2.1)c 1.6 (1.3–2.1)c 1.5 (1.3–1.6)c 1.4 (1.1–1.6)c 1.5 (1.3–1.8)c 1.6 (1.2–2.1)c 1.8 (1.6–2.1)c 1.4 (1.2–1.6)c
  Agoraphobia without panic 1.4 (1.1–1.8) 1.8 (1.4–2.2) 1.3 (0.8–2.0) 2.2 (1.0–4.5) 1.6 (1.2–2.0) 1.6 (1.2–2.4) 1.3 (0.9–2.1) 2.0 (1.1–3.6) 1.6 (1.1–2.4) 1.3 (0.8–2.1)
  Posttraumatic stress disorder 1.8 (1.6–2.1)c 1.9 (1.7–2.2)c 2.1 (1.6–2.7)c 1.7 (1.1–2.6)c 1.3 (1.1–1.6)c 1.4 (1.0–1.9)c 1.9 (1.4–2.5)c 1.6 (1.1–2.3)c 2.3 (1.9–2.9)c 1.3 (1.0–1.8)c
  Obsessive-compulsive disorder 1.4 (1.0–1.9)c 2.1 (1.7–2.6)c 1.6 (1.1–2.5)c 1.5 (0.6–3.8) 1.3 (0.9–1.8) 1.2 (0.6–2.3) 0.7 (0.4–1.5) 1.9 (0.8–4.5) 2.0 (1.2–3.6)c 1.8 (1.0–3.2)
Impulse control disorder
  Intermittent explosive disorder 1.6 (1.4–2.0)c 2.3 (2.0–2.6)c 1.6 (1.1–2.4)c 1.9 (1.1–3.3)c 1.5 (1.2–1.8)c 1.8 (1.3–2.5)c 1.3 (0.9–2.0) 3.0 (2.0–4.7)c 2.0 (1.5–2.5)c 1.5 (1.0–2.2)c
  Bulimia nervosa 1.5 (1.0–2.2)c 2.1 (1.6–2.7)c 1.9 (0.9–3.9) 3.3 (1.4–8.0)c 2.3 (1.7–3.2)c 3.6 (2.0–6.6)c 1.3 (0.8–2.4) 0.7 (0.2–2.3) 1.6 (0.9–2.9) 1.6 (0.8–3.0)
  Binge-eating disorder 1.7 (1.3–2.3)c 2.0 (1.5–2.6)c 1.4 (0.8–2.6) 1.5 (0.7–3.4) 2.0 (1.4–2.7)c 3.4 (2.0–5.9)c 2.1 (1.4–3.2)c 1.4 (0.7–2.5) 1.6 (1.0–2.5)c 1.6 (0.9–3.0)
Substance use disorder
  Alcohol abuse 1.6 (1.4–1.8)c 1.4 (1.3–1.6)c 1.7 (1.4–2.1)c 2.1 (1.5–3.0)c 1.6 (1.4–1.8)c 1.3 (1.1–1.6)c 1.6 (1.3–2.0)c 2.4 (1.8–3.2)c 1.6 (1.4–1.9)c 1.4 (1.1–1.8)c
  Alcohol dependence 1.7 (1.4–2.0)c 1.6 (1.4–1.9)c 2.3 (1.8–3.0)c 2.8 (1.5–5.0)c 1.8 (1.5–2.1)c 1.5 (1.1–2.1)c 2.1 (1.5–2.8)c 2.0 (1.3–3.2)c 1.9 (1.5–2.4)c 1.4 (1.0–2.0)
  Drug abuse 1.9 (1.6–2.2)c 1.6 (1.4–1.9)c 2.2 (1.6–3.0)c 1.9 (1.1–3.3)c 1.9 (1.6–2.2)c 1.8 (1.2–2.5)c 1.4 (1.0–2.0) 1.9 (1.3–2.8)c 2.0 (1.6–2.5)c 1.3 (0.9–2.1)
  Drug dependence 2.1 (1.7–2.7)c 1.8 (1.4–2.3)c 1.7 (1.1–2.6)c 1.9 (0.9–3.9) 2.1 (1.6–2.8)c 2.5 (1.5–4.1)c 1.2 (0.7–2.0) 1.7 (0.9–3.3) 2.3 (1.8–3.1)c 1.4 (0.8–2.7)

Abbreviation: OR, odds ratio.

a

Each mental disorder was estimated as a predictor of the physical condition onset in a separate discrete time survival model controlling for age cohorts, sex, person-years, country, smoking (current, ever, or never), and respondent’s educational level.

b

Respondent reported any of the following: chronic back or neck pain, frequent or severe headaches, and other chronic pain condition.

c

Significant at P < .05, 2-sided test.