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. Author manuscript; available in PMC: 2017 Mar 2.
Published in final edited form as: JAMA Psychiatry. 2016 Feb;73(2):150–158. doi: 10.1001/jamapsychiatry.2015.2688

Table 3.

Bivariate and Multivariate Associations Between DSM-IV Mental Disorder Classes and the Subsequent Onset or Diagnosis of Chronic Physical Conditions

Mental Disorder Chronic Physical Condition, OR (95% CI)
Arthritis Any Chronic Paina Heart Disease Stroke Hypertension Diabetes
Mellitus
Asthma Chronic Lung
Disease
Peptic Ulcer Cancer
Bivariate modelb
  Any mood disorder     1.6 (1.5–1.8)c     1.7 (1.6–1.8)c     1.5 (1.3–1.7)c   1.6 (1.3–2.1)c     1.4 (1.2–1.5)c   1.4 (1.2–1.6)c   1.6 (1.3–1.8)c   2.1 (1.7–2.7)c     1.7 (1.5–1.9)c   1.2 (1.0–1.5)c
  Any anxiety disorder     1.5 (1.4–1.7)c     1.9 (1.8–2.0)c     1.8 (1.6–2.0)c   1.6 (1.2–2.0)c     1.5 (1.4–1.6)c   1.3 (1.1–1.5)c   1.5 (1.3–1.8)c   1.7 (1.3–2.3)c     1.8 (1.6–2.1)c   1.2 (1.0–1.4)c
  Any impulse control
disorder
    1.6 (1.4–1.9)c     2.2 (2.0–2.4)c     1.6 (1.2–2.2)c   2.0 (1.3–3.1)c     1.7 (1.4–1.9)c   2.1 (1.6–2.7)c   1.5 (1.1–2.1)c   2.6 (1.7–3.8)c     1.9 (1.5–2.4)c   1.6 (1.2–2.1)c
  Any substance use
disorder
    1.6 (1.4–1.8)c     1.5 (1.4–1.6)c     1.7 (1.4–2.0)c   2.2 (1.6–3.1)c     1.6 (1.5–1.8)c   1.4 (1.1–1.7)c   1.7 (1.4–2.0)c   2.4 (1.8–3.2)c     1.6 (1.4–1.9)c   1.4 (1.1–1.8)c
  Any disorder     1.6 (1.5–1.7)c     1.9 (1.8–2.0)c     1.7 (1.5–1.9)c   1.7 (1.4–2.0)c     1.5 (1.4–1.6)c   1.3 (1.1–1.5)c   1.5 (1.3–1.8)c   2.1 (1.6–2.6)c     1.9 (1.7–2.1)c   1.3 (1.1–1.5)c
Multivariate modeld
  Any mood disorder     1.4 (1.3–1.5)c     1.3 (1.2–1.4)c     1.2 (1.0–1.4)c   1.3 (1.0–1.7)     1.1 (1.0–1.3)c   1.3 (1.1–1.5)c   1.3 (1.1–1.6)c   1.7 (1.3–2.1)c     1.3 (1.2–1.5)c   1.1 (1.0–1.3)
  Any anxiety disorder     1.4 (1.3–1.5)c     1.8 (1.7–1.8)c     1.6 (1.4–1.9)c   1.4 (1.1–1.7)c     1.3 (1.2–1.5)c   1.2 (1.0–1.4)   1.3 (1.1–1.6)c   1.3 (1.0–1.7)     1.6 (1.4–1.9)c   1.1 (1.0–1.3)
  Any impulse-control
disorder
    1.3 (1.1–1.5)c     1.7 (1.5–1.9)c     1.2 (0.8–1.7)   1.4 (0.9–2.3)     1.4 (1.2–1.6)c   1.8 (1.4–2.4)c   1.2 (0.9–1.6)   1.8 (1.2–2.6)c     1.4 (1.2–1.8)c   1.4 (1.0–1.9)c
  Any substance use
disorder
    1.4 (1.2–1.6)c     1.2 (1.1–1.3)c     1.5 (1.2–1.8)c   2.0 (1.4–2.8)c     1.5 (1.3–1.6)c   1.2 (1.0–1.5)c   1.5 (1.2–1.8)c   1.9 (1.5–2.6)c     1.4 (1.2–1.6)c   1.3 (1.0–1.7)c
Global, χ42 210.4c 814.0c 112.4c 43.5c 191.4c 47.4c 51.1c 69.9c 174.1c 19.6c
No. of disorderse
  1     1.4 (1.3–1.5)c     1.8 (1.7–1.9)c     1.5 (1.3–1.7)c   1.2 (1.0–1.6)     1.4 (1.2–1.5)c   1.2 (1.0–1.4)   1.3 (1.1–1.6)c   1.8 (1.4–2.2)c     1.6 (1.4–1.8)c   1.3 (1.0–1.5)c
  2     1.6 (1.4–1.8)c     2.2 (2.0–2.3)c     1.8 (1.5–2.1)c   2.2 (1.5–3.1)c     1.6 (1.5–1.8)c   1.3 (1.0–1.6)c   1.5 (1.2–1.8)c   1.8 (1.3–2.7)c     2.0 (1.7–2.4)c   1.3 (1.0–1.6)c
  3     2.0 (1.7–2.3)c     2.2 (2.0–2.5)c     2.3 (1.8–3.0)c   2.3 (1.3–3.9)c     1.7 (1.4–2.0)c   1.7 (1.3–2.1)c   1.9 (1.4–2.5)c   3.7 (2.5–5.5)c     2.5 (2.0–3.1)c   1.4 (1.0–1.9)c
  4     2.2 (1.9–2.6)c     2.2 (1.9–2.6)c     2.4 (1.7–3.2)c   2.9 (1.8–4.6)c     1.6 (1.3–1.9)c   1.8 (1.2–2.5)c   2.7 (1.9–3.9)c   2.9 (1.7–5.0)c     2.9 (2.1–4.1)c   1.2 (0.8–1.6)
  ≥5     2.7 (2.2–3.2)c     2.8 (2.4–3.2)c     2.7 (1.9–3.9)c   3.2 (2.0–5.1)c     2.4 (2.0–2.9)c   2.7 (2.0–3.7)c   2.4 (1.8–3.4)c   4.0 (2.5–6.5)c     3.0 (2.3–3.9)c   1.9 (1.4–2.7)c
Global, χ52 220.7c 821.7c 111.9c 47.8c 178.1c 52.3c 45.5c 55.2c 169.9c 19.5c

Abbreviation: OR, odds ratio.

a

Respondent reported any of the following: chronic back or neck pain, frequent or severe headaches, and other chronic pain condition.

b

Each mental disorder class was estimated as a predictor of the physical condition onset in a separate discrete time survival model controlling for age cohorts, sex, person-years, country, smoking (current, ever, or never), and respondent's educational level.

c

Significant at P < .05, 2-sided test.

d

This type of model was estimated with dummy variables for all mental disorder classes entered simultaneously, including the controls.

e

This type of model was estimated with dummy variables for the number of mental disorders without any information about type of mental disorders, including the controls.