Table 2.

Cardiovascular and psychometric outcomes, with ranges in parentheses. Heart rate, blood pressure, excitement, and alertness are averages of morning and afternoon sessions, and change scores are deltas between morning and afternoon. Therapy and sleep durations are totals over the day. There were no significant differences between conditions for any outcome

	Placebo		Theophylline
	Average	Change	Average	Change
Heart Rate (beats/min)	73 (46–85)	0 (–20–10)	75 (48–100)	6.5 (–15–16)
Systolic Blood Pressure (mmHg)	133 (113–151)	−1.5 (–22–18)	134 (116–168)	0 (–28–16)
Diastolic Blood Pressure (mmHg)	81 (72–87)	2 (–18–14)	84 (66–102)	−1 (–20–12)
Excitement	7.5 (3.0–10.0)	0 (–5.0–2.0)	8.3 (2.5–10.0)	0 (–1.0–2.5)
Alertness	7.3 (4.0–9.5)	−1.0 (–6.0–4.0)	6.8 (4.5–10.0)	0 (–5.0–7.0)
Therapy duration (h)	0.3 (0–1.5)		0.2 (0–2.0)
Sleep duration (h)	7.5 (4.5–10.0)		6.8 (4.0–9.2)