FIG. 4.

Redox dysfunction with aging in WT and Sod^−/− spermatocytes and efficient management of oxidative stress in spermatocytes from Cat^−/− mice following SIN-10 induced oxidative insult. Schematic of SIN-10 induced ROS generation (A). Overall ROS, measured using CellROX, showed efficient removal of ROS in all young animals, WT (B), Cat^−/− (C), and Sod^−/− (D). While aged Cat^−/− mice responded to SIN-10 with removal of ROS, aged WT and Sod^−/− did not efficiently remove ROS following SIN-10 treatment (D). Mean values shown with error bars (±SEM); one-way ANOVA with Newman-Keuls; **P < 0.01, n = 4–5.