FIG. 2.

Role of KLF10 on disease phenotype and lesion size. A, B, C) Endometriosis was surgically induced in 8-wk-old wt and Klf10^−/− female mice (n = 7/group). At induction, 0.5 cm endometrial implants were sutured onto the parietal peritoneum of both groups. Lesion size, morphometry, and disease phenotype were evaluated 3 wk later at necropsy. Peritoneal lesions (circles and arrows) in Klf10^−/− animals were larger, cystic, and associated with an inflammatory exudate (B). In contrast, wt mice showed lesion regression and minimal to no fibrosis or inflammatory exudate (A). Average lesion size of Klf10^−/− animals was significantly greater (>2 fold) than wt (C). Error bars represent standard deviation (*P < 0.05). D, E) Histochemical analysis using hematoxylin and eosin revealed Klf10^−/− lesions to be associated with a large neutrophilic infiltrate and complete obliteration of normal glands and stroma. In contrast, wt lesions had normal appearing glands and stroma. Magnification ×100 (A, B, D, E).