FIG. 3.

Loss of KLF10^−/− demonstrates a predominately inflammatory response with minimal fibrosis. Endometriotic lesions in Klf10^−/− mice were associated with prolific inflammation with associated infiltrate and minimal associated fibrosis. A) Wild-type animal demonstrating endometrial implant regression (arrow). Lesions were discrete and not physically adherent to surrounding peritoneum or abdominal viscera at time of necropsy. B) Klf10^−/− animal demonstrating significant inflammatory infiltrate and minimal fibrosis (arrow: lesion). These lesions were associated with no or minimal easily ruptured adhesions to surrounding structures. There was also no associated mesenteric shortening. C) Klf11^−/− animal demonstrating dense fibrosis of bowel to peritoneal lesion (arrow). In contrast to wt and Klf10^−/− animals, lesions in Klf11^−/− were nondiscrete and encased in adhesions to surrounding peritoneum and abdominal viscera. D) A murine fibrosis adhesion score was utilized to evaluate overall fibrosis in the endometriosis model. Klf11^−/− animals demonstrate significantly higher fibrosis scores (>8 fold when compared to wt and >4 fold when compared to Klf10^−/−). Error bars represent standard deviation (*P < 0.05). E) Induction of endometriosis, despite varying phenotypes, did not alter animal weights. Error bars represent standard deviation.