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. 2017 Mar 9;2(5):e91127. doi: 10.1172/jci.insight.91127

Figure 3. Reduced retinoic-acid-orphan-receptor-C–dependent (RORC-dependent) target gene expression by cpds 1 and 2.

Figure 3

CD4+ Th17 cells were treated with compounds (10 nM–1 μM) or with DMSO only (Co) during 72 hours, mRNA was extracted, and transcript levels were quantified by RT-PCR. Gene expression was normalized to β-glucoronidase levels and expressed as arbitrary units. (A–G) All graphs are representative of 3 independent experiments. Individual data and mean ± SD from triplicate readings are shown. The DMSO control shown in the cpd 1 panel in D consisted of 2 readings.