Figure 3. Treg suppressive deficiency correlates with disease burden and rate of disease progression.
(A) There is a correlation between burden of disease (Appel ALS [AALS] points) at blood draw and the level of Treg suppression of responder T lymphocyte (Tresp) proliferation at the 1:1/2 Tresp/Treg ratio. (B) There is a correlation between the rates of disease progression (AALS points/month) at blood draw and Treg suppression of Tresp proliferation. P values obtained by Pearson correlation.