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. 2017 Mar 9;2(5):e90780. doi: 10.1172/jci.insight.90780

Figure 4. Bile acid induction of Cxcl2 in mouse hepatocytes is reduced after inhibition of the bile acid transporter Ntcp.

Figure 4

(A) Ntcp knockdown reduced taurocholic acid (TCA) induction of Cxcl2 mRNA expression. Forty-eight hours after siRNA transfection, cells were treated with TCA for an additional 24 hours. Results are the mean ± SD, n = 4. *P < 0.05 by 1-way ANOVA. (B) Biotinylated cholic acid (BCA) and ursodeoxycholic acid (BUDCA) reduced TCA and glycocholic acid (GCA) induction of Cxcl2. Cells were treated with the indicated inhibitors for 6 hours (mean ± SD, n = 4). *P < 0.05 by 1-way ANOVA.