Table 1.
Clinical characteristics of families a, b and c
| Family | ID | Diagnosis | BMI (kg/m2) | Glucose (mmol/l) | C-peptide (nmol/l) | Insulin (pmol/l) | ||
|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||
| FPG | 2 h PG | FINS | 2 h INS | |||||
| a | II-1 | DM | 21.0 | 16.0 | – | 0.03 | – | – |
| II-2 | DM | 18.4 | 14.4 | – | 0.07 | – | – | |
| II-4 | DM | 20.6 | 8.1 | 12.7 | – | 50.0 | 104.9 | |
| III-1 | IGT | 20.3 | 5.1 | 8.1 | – | 61.8 | 200.0 | |
| III-2 | DM | 21.0 | 5.9 | 11.5 | – | 43.1 | 134.0 | |
| b | II-1 | DM | 24.5 | 14.0 | – | 0.13 | – | – |
| III-1 | DM | 32.4 | 12.0 | – | 0.10 | – | – | |
| III-2 | DM | 28.4 | 5.2 | 13.0 | – | 68.8 | 137.5 | |
| III-3 | DM | 25.2 | 7.8 | 16.7 | – | 59.7 | 175.0 | |
| c | II-1 | DM | 23.6 | 7.2 | 11.8 | 0.13 | – | – |
| III-1 | DM | 26.2 | 8.3 | 13.1 | – | 41.0 | 150.0 | |
| IV-1 | IGT | 22.8 | 5.8 | 8.2 | – | 55.6 | 224.3 | |
| 166 cases | DM | 24.3±3.4 | 9.5±4.1 | 15.4±4.8 | 0.70±0.05 | 127.8±97.2 | 304.2±192.4 | |
Other clinical characteristics of the mutation carriers are shown. For comparison, means ± SD for the same characteristics in a group of 166 individuals with type 2 diabetes are shown. DM, diabetes mellitus; 2 h INS, 2 h plasma insulin; FINS, fasting plasma insulin; 2 h PG, 2 h plasma glucose; FPG, fasting plasma glucose