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. 2017 Feb 17;6(2):e130. doi: 10.1038/cti.2016.89

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Copyright © 2017 The Author(s)

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Outlines of the GQM for BCR-mediated B-cell regulation. (a) Identical BCR engagement due to interactions with different apparent affinity is reached at different antigen concentrations. (b) BCR engagement, as determined by apparent affinity and free antigen concentration at equilibrium, regulates B-cell survival. Green line indicates the comfort zone of the cells. (c) Strategies for survival at BCR under- and overengagement.