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. 2017 Feb 17;6(2):e130. doi: 10.1038/cti.2016.89

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Copyright © 2017 The Author(s)

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Development of B cells in the bone marrow. Pre-BI cells receive proliferation signals via the pre-BCR, entering several rounds of cells division. Cycling large pre-BII cells come to rest when they lose SLC, and start rearranging their light chains. Pre-BI small cells forming a signaling fit BCR reach their comfort zone and survive as immature B cells, other rearrange another light chain locus or die. Immature B cells leave the bone marrow.