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Differentiation of immature B cells in blood. Circulating B cells that receive moderate supraoptimal BCR signals may remain in a continuously activated state, dividing from time-to-time and secreting antibodies as BI cells. Otherwise these cells may differentiate into MZB cells and settle at antigen-trapping sites such as the marginal zone. Upon activation, these cells may switch their heavy chain isotype in an attempt to increase apparent affinity of their BCR.
