Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Feb 26;23:39–51.

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2017 Molecular Vision.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited, used for non-commercial purposes, and is not altered or transformed.

PMC Copyright notice

Analysis of EBM component mRNAs in the anterior stroma at 7 days after PRK with quantitative real-time PCR. Nidogen-1 mRNA was statistically significantly increased in the anterior stroma of the −4.5D photorefractive keratectomy (PRK) and –9.0D PRK corneas compared to the unwounded control corneas, but the PRK groups were not statistically significantly different from each other. The nidogen-2 mRNA was statistically significantly higher in the anterior stroma of the −4.5D PRK corneas at this time point just before ultrastructural epithelial basement membrane (EBM) regeneration compared to the −9.0D PRK corneas that are destined to not have ultrastructural EBM regeneration, and only the −4.5D PRK group was statistically significantly higher than the unwounded control group. LAMA3 mRNA was statistically significantly increased in the anterior stroma of the −4.5D PRK corneas at 7 days after surgery compared to the −9.0D PRK corneas or the unwounded control corneas. The difference between the −9.0D PRK corneas and the unwounded control corneas for LAMA3 did not reach statistical significance. The perlecan mRNAs were not statistically significantly increased in the anterior stroma of the PRK corneas from either group or the unwounded control corneas group. (n = 4 for each group; ***, p<0.01).