Table 3. Summary of significant differences in the reporting of all grades and severe (CTCAE grade ≥3) all-causality adverse events over day 0–90 from first RE procedure in A. Patients with and without abnormal baseline laboratory parameters and B. In patients with at least grade 2 baseline laboratory parameters compared with those no or only mild changes in baseline laboratory parameters.

System organ, class	Baseline CTCAE grade ≥1 vs. Grade 0							Baseline CTCAE grade ≥2 vs. Grade ≤1
	Bilirubin (n=37)	Albumin (n=199)	Alk Phos (n=351)	ALT (n=175)	AST (n=294)	Hemoglobin (n=238)		Albumin (n=72)	Alk Phos (n=99)	Hemoglobin (n=58)
Total	Grade ≥3	Grade ≥3	Grade ≥3*, all grades*		Grade ≥3*, all grades			Grade ≥3*
Gastrointestinal						All grades
Abdominal pain						All grades
Nausea						All grades*		All grades
Abdominal distension										All grades
Intestinal obstruction		All grades
Flatulence										All grades
Constitutional	Grade ≥3	Grade ≥3	Grade ≥3*, all grades		Grade ≥3*, all grades			Grade ≥3
Fatigue	Grade ≥3	Grade ≥3	Grade ≥3*, all grades		Grade ≥3*
Fever			All grades*	All grades	All grades*
Peripheral edema									Grade ≥3
Psychiatric	All grades		All grades
Anorexia nervosa	All grades
Hepatobiliary	Grade ≥3*, all grades*	Grade ≥3	All grades*	All grades	All grades*			Grade ≥3*, all grades*	Grade ≥3*, all grades*
Hyperbilirubinemia	All grades*	Grade ≥3, all grades	All grades*	All grades*	All grades*			Grade ≥3*, all grades*	Grade ≥3*, all grades*	Grade ≥3
Ascites	All grades
REILD	Grade ≥3, all grades
Hepatic failure	Grade ≥3*, all grades								Grade ≥3, all grades
Respiratory								Grade ≥3
Influenza		All grades

*, P value <0.01. REILD, radioembolization-induced liver disease; CTCAEs, Common Terminology Criteria Adverse Events; AST, aspartate aminotransferase; ALT, alanine transaminase; Alk phosph, alkaline phosphatase;.