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. Author manuscript; available in PMC: 2017 Aug 8.
Published in final edited form as: Nature. 2017 Feb 8;543(7643):122–125. doi: 10.1038/nature21356

Fig. 2. ECDNA is found in nearly half of cancers and contributes to intra-tumoral heterogeneity.

Fig. 2

a, Distribution of ECDNA per metaphase from 72 cancer, 10 immortalized and 8 normal cell cultures, Wilcoxon rank sum test. b, ECDNA distribution per metaphase stratified by tumor type. c, Proportion of samples with ≥ 2 ECDNAs in ≥ 2 per 20 metaphases. Data shown as mean ± SEM. (methods). d, Proportion of tumor cultures positive for ECDNA by tumor type. e, Shannon diversity index (SI). Each dot represents an individual cell line sampled with ≥ 20 metaphases. f, SI by tumor type. g, DAPI-stained metaphases with histograms.