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. Author manuscript; available in PMC: 2017 Aug 8.
Published in final edited form as: Nature. 2017 Feb 8;543(7643):122–125. doi: 10.1038/nature21356

Fig. 4. Theoretical model for focal amplification via extrachromosomal (EC) and intrachromosomal (HSR) mechanisms.

Fig. 4

Simulated change in copy number via random segregation (EC) or mitotic recombination (HSR), starting with 105 cells, 100 of which carry amplifications. a, The selection function f100(k) reaches maximum for k=15, then decays logistically. b, Growth in amplicon copy number over time. c, DNA copy number stratified by oncogene location. (p<0.001, ANOVA/Tukey’s multiple comparison). N=52; data points include top five amplified oncogenes, mean ± SEM. d, Change in heterogeneity (SI) over time. e, Correlation between copy number and heterogeneity. f, Experimental data showing correlation between ECDNA counts and heterogeneity matches the simulation in panel E.