FIGURE 4.

Results from reference region–based analyses with cerebellar input functions. (A) Demonstration of Logan plot linearization in MCI subject (subject 9) for estimation of DVR. Large circles depict 55-min t* point. Axes were scaled down to enhance visualization of higher uptake regions. Comparison of Logan DVR (B) and SUVR_80–100 (C) against indirect calculations of DVR given $V_{\text{T}}/V_{\text{T}}^{\text{ref}}$ with distribution volumes estimated by compartmental modeling with arterial input functions and $V_{\text{T}}^{\text{ref}}$ corresponding to cerebellum. CB = cerebellum; PC = parietal cortex; PCg = posterior cingulate gyrus; PCUN = precuneus; MTC = mesial temporal cortex.