Table 3.
Cases/Cont rols a |
DII quintiles, OR (95% CI)b |
p value for trend |
p value for interacti on |
|||||
---|---|---|---|---|---|---|---|---|
−6.18, −2.13 | −2.12,−1.09 | −1.08,−0.04 | −0.03, 1.28 | 1.28, 5.14 | ||||
Age | 0.62 | |||||||
<55 years | 1242/1166 | 1 c | 1.06 (0.82, 1.37) | 1.38 (1.05, 1.81) | 1.34 (1.01, 1.79) | 1.76 (1.25, 2.47) | <0.001 | |
≥55 years | 1327/1422 | 1c | 1.67 (1.28, 2.16) | 1.34 (1.02, 1.76) | 1.48 (1.11, 1.98) | 1.76 (1.28, 2.42) | 0.01 | |
BMI | 0.38 | |||||||
<25kg/m2 | 1392/1345 | 1c | 1.20 (0.93, 1.54) | 1.34 (1.03, 1.75) | 1.40 (1.06, 1.86) | 1.61 (1.16, 2.22) | 0.002 | |
≥25kg/m2 | 1170/1235 | 1c | 1.51 (1.15, 1.98) | 1.39 (1.05, 1.85) | 1.41 (1.05, 1.91) | 1.90 (1.36, 2.66) | 0.25 | |
Parity | 0.48 | |||||||
Nulliparous | 401/380 | 1c | 1.31 (0.77, 2.22) | 1.67 (0.98, 2.83) | 1.44 (0.83, 2.52) | 1.78 (0.96, 3.31) | 0.04 | |
Parous | 2165/2206 | 1c | 1.34 (1.10, 1.63) | 1.32 (1.07, 1.62) | 1.44 (1.16, 1.80) | 1.78 (1.39, 2.29) | 0.10 | |
Menopausal status | 0.71 | |||||||
Pre/peri- menopause |
987/842 | 1c | 1.08 (0.81, 1.45) | 1.43 (1.05, 1.95) | 1.48 (1.06, 2.06) | 1.60 (1.08, 2.36) | 0.52 | |
Post-menopause | 1579/1746 | 1c | 1.51 (1.19, 1.91) | 1.34 (1.04, 1.72) | 1.40 (1.08, 1.82) | 1.85 (1.38, 2.48) | 0.007 | |
Family history of female-hormone related cancers |
0.98 | |||||||
Yes | 396/233 | 1c | 1.44 (0.82, 2.51) | 1.37 (0.75, 2.49) | 1.12 (0.61, 2.05) | 1.85 (0.89, 3.81) | 0.30 | |
No | 2173/2355 | 1c | 1.32 (1.08, 1.60) | 1.34 (1.10, 1.65) | 1.43 (1.15, 1.77) | 1.74 (1.36, 2.23) | 0.03 | |
Energy intaked | 0.11 | |||||||
<2081 kcal | 1405/1294 | 1c | 1.26 (0.98, 1.61) | 1.17 (0.91, 1.50) | 1.24 (0.96, 1.61) | 1.25 (0.95, 1.64) | 0.17 | |
≥2081 kcal | 1164/1294 | 1c | 1.12 (0.85, 1.47) | 1.23 (0.94, 1.61) | 1.27 (0.98, 1.64) | 1.30 (1.01, 1.67) | 0.03 |
The sum may not add up to the total because of some missing values.
Adjusted for quinquennia of age, study centre, energy intake, education, body mass index, parity, menopausal status and family history of hormone-related cancers, when appropriate.
Reference category.
Median energy intake among controls.