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. 2017 Mar 2;11:21. doi: 10.1186/s13065-017-0248-6

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Response surface plots; the interaction effect of a overhead stirring time and the cycle of high pressure homogenizer; b high shear time and the cycle of high pressure homogenizer; c shear rate and the cycle of high pressure homogenizer on response (particle size)