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Schematic of TLR, IL-1, IL-6 and interferon receptor activation of NFκB and JAK-STAT signalling and transcriptional control. The effects of A2AR KO- on LPS-dependent gene changes are highlighted. These pathways are critical to cellular responses to LPS and orchestration of inflammation. Specific effects of A2AR activity (based on effects of receptor KO) on transcriptional responses to LPS are highlighted (red—increased expression; blue—reduced expression)
