Table 4.
Top 20 biological and toxicological functions modified by A2AAR KO in healthy myocardium
| Biological pathway | P values | Genes |
|---|---|---|
| Cellular development | 7.34E-04–4.5E-02 | Mrap, Ctsk, Sacs, Prkar2b, Ptger3, Nfatc2, Tslp, Map3k2 |
| Cellular growth and proliferation | 7.34E-04–4.01E-02 | Mrap, Ppbp, Nfatc2, Tslp |
| Haematological system development and function | 7.34E-04–4.5E-02 | Hp, Ptger3, Ticam1, Ppbp, Nfatc2, Tslp, Map3k2 |
| Humoral immune response | 7.34E-04–4.5E-02 | Nfatc2, Fmod, Tslp |
| Cell-to-cell signalling and interaction | 1.53E-03–4.74E-02 | Ank3, Ptger3, Ticam1, Ppbp, Nfatc2, Iqgap1, Tslp, Map3k2 |
| Amino acid metabolism | 2.55E-03–5.09E-03 | Slc38a1 |
| Carbohydrate metabolism | 2.55E-03–4.72E-02 | Gnb1, Pon1, Ppbp, Ppa1 |
| Cell death | 2.55E-03–4.5E-02 | Ppbp, Nfatc2, Tslp, Map3k2 |
| Cell morphology | 2.55E-03–3.68E-02 | Ank3, Ptger3, Nfatc2, Cnpy2, Iqgap1, Tslp |
| Cellular assembly and organization | 2.55E-03–4.01E-02 | Ank3, Ctsk, Nfatc2, Fmod, Cnpy2, Iqgap1, Acta1 |
| Cellular compromise | 2.55E-03–4.01E-02 | Ank3, Hp, Ctsk, Ptger3, Ppbp |
| Cellular function and maintenance | 2.55E-03–1.52E-02 | Hp, Ppbp, Nfatc2, Tslp, Map3k2 |
| Cellular movement | 2.55E-03–4.58E-02 | Gnb1, Ctsk, Hp, Ticam1, Ppbp, Nfatc2, Iqgap1, Tslp |
| Connective tissue development and function | 2.55E-03–3.02E-02 | Ctsk, Rpl22, Ptger3, Pde3b, Ppbp, Cidec, Nfatc2 |
| Connective tissue disorders | 2.55E-03–5.09E-03 | Nfatc2 |
| Developmental disorder | 2.55E-03–2.55E-03 | Ctsk |
| Genetic disorder | 2.55E-03–4.01E-02 | Ank3, Ctsk, Ptger3, Cidec, Iqgap1, Tslp, Mrap, Gnb1, Pon1, Hp, Prkar2b, Pde3b, Nfatc2, Dgat1, Acta1 |
| Hair and skin development and function | 2.55E-03–5.09E-03 | Ptger3, Dgat1 |
| Immune cell trafficking | 2.55E-03–3.51E-02 | Hp, Ticam1, Ppbp, Nfatc2, Tslp |
| Inflammatory response | 2.55E-03–4.67E-02 | Hp, Ptger3, Ticam1, Ppbp, Nfatc2, Fmod, Tslp |
| Molecular toxicological function | P values | Genes |
| Liver fibrosis | 3.01E-03 | Hp, Tslp |
| Liver damage | 1.43E-02 | Ticam1, Tslp |
| Liver steatosis | 2.45E-02 | Pde3b |
| Cardiac arteriopathy | 3.41E-02 | Ank3, Cux2, Dgat1, Gk5, Nsmce1, Pde3b, Pon1 |
| Cardiac infarction | 3.76E-02 | Acta1, Pon1 |
| Liver hepatitis | 4.41E-02 | Pde3b |
| Hepatocellular carcinoma | 4.43E-02 | Hp, Iqgap1 |
| Liver steatohepatitis | 5.67E-02 | Pde3b |
| Renal proliferation | 7.90E-02 | Tslp |
| Liver inflammation | 9.36E-02 | Hp |
| Pulmonary hypertension | 1.08E-01 | Ptger3 |
| Nephrosis | 1.10E-01 | Pde3b |
| Cardiac congestive cardiac failure | 1.63E-01 | Pde3b |
| Heart failure | 1.63E-01 | Pde3b |
| Renal nephritis | 2.50E-01 | Pde3b |
Enriched biological/toxicological functions of A2AR KO sensitive transcripts are listed according to P values or ranges determined by a Fisher’s Exact Test