. 2016 Oct 20;13(1):89–103. doi: 10.1007/s11302-016-9542-3

Table 3.

Evaluation of AR-C118925 (3) and its derivative 5 on adenosine receptors using radioligand receptor binding assays

Receptor	K _i value (μM) (or % inhibition at indicated concentration)
Receptor	AR-C118925 (3)	Derivative 5
Human adenosine A₁	>>1 (1 % at 1 μM)^b	>>1 (−10 % at 1 μM)^b
Human adenosine A_2A	9.16 ± 1.57^a	>10 (17 % at 10 μM)^b
Human adenosine A_2B	>>1 (−4 % at 1 μM)^b	>1 (−43 % at 1 μM)^c
Human adenosine A₃	≥10 (44 % at 10 μM)^b	11.2 ± 2.3^a

Mean IC50 values are presented in bold followed by SEM

^a n = 3

^b n = 2

^c n = 1