Table 3.
Receptor | K i value (μM) (or % inhibition at indicated concentration) | |
---|---|---|
AR-C118925 (3) | Derivative 5 | |
Human adenosine A1 | >>1 (1 % at 1 μM)b | >>1 (−10 % at 1 μM)b |
Human adenosine A2A | 9.16 ± 1.57a | >10 (17 % at 10 μM)b |
Human adenosine A2B | >>1 (−4 % at 1 μM)b | >1 (−43 % at 1 μM)c |
Human adenosine A3 | ≥10 (44 % at 10 μM)b | 11.2 ± 2.3a |
Mean IC50 values are presented in bold followed by SEM
a n = 3
b n = 2
c n = 1