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. 2016 Oct 20;13(1):89–103. doi: 10.1007/s11302-016-9542-3

Table 3.

Evaluation of AR-C118925 (3) and its derivative 5 on adenosine receptors using radioligand receptor binding assays

Receptor K i value (μM) (or % inhibition at indicated concentration)
AR-C118925 (3) Derivative 5
Human adenosine A1 >>1 (1 % at 1 μM)b >>1 (−10 % at 1 μM)b
Human adenosine A2A 9.16 ± 1.57a >10 (17 % at 10 μM)b
Human adenosine A2B >>1 (−4 % at 1 μM)b >1 (−43 % at 1 μM)c
Human adenosine A3 ≥10 (44 % at 10 μM)b 11.2 ± 2.3a

Mean IC50 values are presented in bold followed by SEM

a n = 3

b n = 2

c n = 1