Figure 1.

p300/CREB-binding protein (CBP) regulate the cell cycle at multiple points. The diagram summarizes the known functions of p300/CBP at different points along the cell cycle. The E2F family of transcription factors uses p300/CBP as transcriptional coactivators to facilitate expression of E2F target genes that orchestrate the transition from G₁ to S. p300 also facilitates S phase progression by acetylating the DNA replication machinery (e.g., FEN1 and Dna2) and the histones surrounding the replication origins (e.g., H3K18). CBP promotes progression through mitosis by regulating the function of the anaphase-promoting complex (APC)/C complex.