Figure 3.

The acetyltransferase domains of p300 and CBP are hotspots for mutations in cancer. (A) The number of tumors of different origins with missense mutations along the p300 and CBP proteins domain structures is shown (Forbes et al. 2015). CH1, Cysteine/histidine-rich region 1; BR, bromodomain; PHD, plant homeodomain finger; RING, Really Interesting New Gene finger domain; KAT, lysine acetyltransferase domain; CH3, cysteine/histidine-rich region 3 (also referred to as TAZ2); IBiD, IRF3-binding domain. (B) The residues in the KAT domains of p300 and CBP that are frequently mutated in cancer are indicated. Residues in red are important for the KAT activity. The four most common residues mutated in p300 reside close to the acetyl-CoA-binding site as indicated in the crystal structure (Liu et al. 2008; Maksimoska et al. 2014).