Figure 2.

Schematic of TP53 mutation in hypodiploid ALL and the Catalog of Somatic Mutations in Cancer (COSMIC) database. Hypodiploid mutations are shown on the top of the figure and all TP53 mutations from the COSMIC database are shown on the bottom, with mutations of the same residues selected as those mutated in hypodiploid ALL. The majority of mutations are missense mutations and they are located within the DNA-binding domain. The nonsense R306* mutation occurs in the bipartite nuclear localization sequence (NLS) domain.