Figure 4. Distribution of Maximum PD-L1 score among 5 Pathologists.

A) A histogram of all chromogenic immunohistochemistry data for tumor: the raw percentage of staining assigned by each of the 5 pathologists for each of the 3 blocks, per case (15 bars per case, color coded by block as shown in the inset). B) the distribution of the single maximum score provided by each of the 5 pathologists among all 3 blocks per case from tumor regions (5 data points per case). Each boxplot represents 25^th%-, median-, and 75^th% readings, with the whiskers denoting minimum and maximum percentages of these 5 data points. The y-axis labels the maximum reading among the 3 blocks. C) shows a histogram of all chromogenic immunohistochemistry data for stroma: the raw percentage of staining assigned by each of the 5 pathologists for each of the 3 blocks, per case (15 bars per case, color coded by block as shown in the inset). D) the distribution of the single maximum score provided by each of the 5 pathologists among all 3 blocks per case from stromal regions (5 data points per case). Each boxplot represents 25^th%-, median-, and 75^th% readings, with the whiskers denoting minimum and maximum percentages of these 5 data points. The y-axis labels the maximum reading among the 3 blocks.