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Tissue iron concentration at 3 days after tail vein injection of 1000 mg iron isomlatoside or vehicle only compared to animals without any iron deficiency. Note the increased peripheral iron corrects the iron deficiency in the ventral mid-brain and nucleus accumbens without increasing iron in the brain regions without iron deficiency. Iron overload in the brain does not seem to occur. (from Unger, et al, Neuroscience (2013) 246c:179-85)
