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. 2017 Mar 3;8:214. doi: 10.3389/fimmu.2017.00214

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Copyright © 2017 Tu, Chen, Zhang and Duan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interleukin (IL)-4 inhibits indoleamine 2,3-dioxygenase (IDO) expression during dendritic cells differentiation. Bone marrow-derived DCs (BMDCs) were propagated from bone marrow cells in GM-CSF (10 ng/ml) and different dose of IL-4 (2, 5, and 10 ng/ml) until day 7. Monocyte-derived DCs (MoDCs) were generated from CD14+ monocytes in GM-CSF (50 ng/ml) and various dose of IL-4 (5, 10, and 20 ng/ml) until day 6. After differentiation, total protein from BMDCs and MoDCs were extracted and subjected to assess IDO expression by immunoblot. All data are representative of one of the three independent experiments.