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. 2017 Mar 3;8:214. doi: 10.3389/fimmu.2017.00214

Figure 7.

Figure 7

The potential of dendritic cells (DCs) generated under low concentration of interleukin (IL)-4 in regulatory T cells differentiation depend on CD103+ DCs. BMDCs and MoDCs were generated under low (BMDC, 2 ng/ml; MoDCs, 5 ng/ml) and high (BMDC, 10 ng/ml; MoDCs, 20 ng/ml) concentration of IL-4 (A). The CD103− DCs were sorted from DCs which generated under low concentration of IL-4 (B). Then these DCs were subjected to cocultured with naïve CD4+ T cells for 5 days in the presence of anti-CD3 (0.5 μg/ml), respectively. Then the cells were collected for analyzing CD4+CD25+Foxp3+ differentiation by flow cytometry. Results are represented as means ± SD (C). The data shown are representative of one of the three separate experiments. *p < 0.05, #p < 0.01.