Figure 3.

(a) Somatic single nucleotide mutation trends. Somatic mutations were primarily C·G‐A·T transversions. Distribution of specific nucleotide changes among germline and somatic variations in the lung adenocarcinoma genome. C·G‐A·T transversions accounted for 56% of high confidence somatic mutations, whereas most germline variations were A·T‐G·C and C·G‐T·A transitions. (b) Somatic single‐nucleotide mutations of all types occurred at a lower frequency on the transcribed strand (TS). TS represent single nucleotide somatic mutation rates, with different types of base substitutions on the coding regions. The non‐transcribed strand (NTS) represents the same classes of mutations occurring on the NTS.