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. 2017 Mar 3;8:114. doi: 10.3389/fphys.2017.00114

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Copyright © 2017 MacMillan, Kapchinsky, Konokhova, Gouspillou, de Sousa Sena, Jagoe, Baril, Carver, Andersen, Richard, Perrault, Bourbeau, Hepple and Taivassalo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in markers of mitochondrial biogenesis and content before (open bars) and after (dark bars) training in COPD patients. (A) EET had no effect on PGC-1α mRNA in contrast to CET. Similarly, (B) EET had no effect on PGC-1α content as detected in situ within specific fiber types, whereas CET led to an overall increase in PGC-1α content. (C) Analysis of electron transport chain complexes revealed no effect of EET, whereas concentric training increased both Complex I and Complex II content. Bar values are means ± SEM. ^**Significant difference compared with pre-training values, p < 0.01.^*Significant difference compared with pre-training values, p < 0.05.