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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Genes Brain Behav. 2016 Oct 21;16(3):342–351. doi: 10.1111/gbb.12343

Figure 5.

Figure 5

Intra-orbitofrontal cortex M100907 increases repetitive self-grooming in BTBR mice. Mean (±SEM) seconds spent grooming. This included the following groups: B6: vehicle (n = 7); BTBR: vehicle (n = 6), 0.2μg M100907 (n = 7), 0.6μg M100907 (n = 7); musicmol (n = 9). Infusion of 0.6μg M100907 into the orbitofrontal cortex significantly elevated grooming duration in BTBR mice compared to vehicle-treated BTBR mice and 0.2 μg M100907 treated mice. Muscimol treatment reduced grooming behavior in BTBR mice compared to vehicle, 0.2μg M100907 and 0.6μg M100907 treated BTBR mice. *p < 0 .01 vs. B6-vehicle; #p < 0.01 vs. BTBR-vehicle, BTBR-0.2μg M100907 and B6-vehicle; @p < 0.05 vs. BTBR-vehicle, BTBR-0.2μg and BTBR-0.6μg M100907.