Table 3.

Hazard ratio (HR) and 95% confidence interval (95%CI) of heart failure in relation to ferritin serum levels (ARIC study, 1987 to 2011)

Categories	Heart failure in the whole population sample						Heart failure in non-anemic participants
	Model 1 n=1063		Model 2 n=1034		Model 3 n=1034		Model 1 n=925		Model 2 n=897		Model 3 n=897
	HR (95%CI)	p	HR (95%CI)	p	HR (95%CI)	p	HR (95%CI)	p	HR (95%CI)	p	HR (95%CI)	p
Normal range (30–200 ng/mL in women and 30–300 ng/mL in men)	Ref	-	Ref	-	Ref	-	Ref	-	Ref	-	Ref	-
Low ferritin (<30 ng/mL)	2.69 (1.36–5.31)	0.004	2.25 (1.13–4.50)	0.025	2.24 (1.15–4.35)	0.018	2.85 (1.35–5.98)	0.006	2.33 (1.08–4.99)	0.030	2.28 (1.11–4.68)	0.026
High ferritin (>200 ng/mL in women and >300 ng/mL in men)	2.00 (1.08–3.67)	0.025	1.86 (1.04–3.35)	0.037	1.81 (1.01–3.25)	0.046	2.15 (1.14–4.05)	0.018	2.09 (1.13–3.85)	0.018	1.97 (1.08–3.59)	0.027

Model 1: adjusted age, sex, and race

Model 2: additionally adjusted for: body mass index, heart rate, hypertension, smoking, alcohol drinking, hemoglobin, C reactive protein, glucose, low-density-lipoprotein cholesterol, glomerular filtration rate, prevalent coronary disease

Model 3: additionally adjusted for: albumin, menopausal status, incidence of anemia, incidence of diabetes and education level.