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. 2017 Mar 3;11:52. doi: 10.3389/fncel.2017.00052

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Copyright © 2017 Huang, Xue, Feng, Yang, Nie, Zhu, Tao, Gao and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of 4-PBA on the 6-OHDA-induced hypo-excitability of DA neurons in the SNc. Plots of spike number vs. injection current and average current of the rheobase in DA neurons in SNc slices treated with 6-OHDA (1 μM) alone (A,B) or with 4-PBA (2 mM) pretreatment for 20 min (C,D). Data are shown as mean ± SEM (n = 10). The Plots of spike number vs. injection current was analyzed via two-way ANOVA, the row factor is injection current while the average current of the rheobase was analyzed via t-test. Rheobase: Control, 67.93 ± 23.47 pA; 6-OHDA 147.5 ± 48.92 pA; Control, 68.75 ± 19.24 pA; 4-PBA+6-OHDA, 71.88 ± 22.17 pA; ^∗P < 0.05 and ^∗∗P < 0.01 vs. the control group. The sketch map was recorded at the injection current was 100 pA.