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. 2017 Mar 3;4(1):ENEURO.0011-17.2017. doi: 10.1523/ENEURO.0011-17.2017

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Copyright © 2017 Kalappa and Tzounopoulos

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 3. — Endocannabinoid signaling is necessary for the zinc-mediated enhancement of EPSC_SS. A, Upper panel, representative traces of AMPA EPSCs, evoked by 50-Hz 20-pulse train, in the presence of 1 µm AM-251 before (gray) and after ZX1 (orange). Lower panel, summary graph showing average ratios of AMPA EPSCs in the presence of ZX1 to that in control during the train (ZX_1–2/control_1–2 vs. ZX_16–20/control_16–20: 50 Hz: n = 5, p = 0.13). B, Upper panel, representative traces of AMPA EPSCs evoked by 50-Hz 20-pulse train in 1.2 mm (gray) and 2.4 mm (orange) external calcium in the presence of AM-251. Lower panel, summary graph showing average AMPA EPSC amplitudes during the train in 1.2 mm (gray) and 2.4 mm (orange) external calcium in the presence of AM-251. (EPSC_16–20 amplitude in AM-251: 1.2 vs. 2.4 mm calcium, n = 5, p = 0. 09). Values represent mean ± SEM. Detailed values and statistical tests: A, lower panel: ZX_1–2/control_1–2 vs. ZX_16–20/control_16–20: 50 Hz: control: 1.47 ± 0.06 vs. ZX1: 1.36 ± 0.08, n = 5, p = 0.13, t = 1.4, df = 9; paired t-test. B, lower panel: EPSC_16–20 amplitude: AM-251: 1.2 mm calcium: 805 pA ± 97 pA vs. 2.4 mm calcium: 921 pA ± 80 pA, n = 5, p = 0.19, F = 1.7, DFn = 1, DFd = 40; two-way ANOVA.