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. 2017 Mar 3;4(1):ENEURO.0011-17.2017. doi: 10.1523/ENEURO.0011-17.2017

Figure 7.

Figure 7.

The postsynaptic inhibitory effect of zinc on AMPA EPSC does not contribute to the zinc-mediated enhancement of synaptic facilitation. A, Representative traces of AMPA EPSCs, evoked by 50-Hz 20-pulse train in the presence of 50 nm WIN 55 212-2, before (gray) and after (maroon) ZX1. B, Summary graph showing average AMPA EPSC amplitudes during the train, normalized to EPSC amplitude elicited by the first pulse, before (gray) and after (maroon) ZX1 (ratio of the amplitude of 16–20 EPSC to first EPSC at 50 Hz: control vs. ZX1, n = 5, p = 0.18). C, Summary graph showing average ratios of AMPA EPSCs in the presence of ZX1 to that in control during the train (ZX1–2/control1–2 vs. ZX16–20/control16–20, n = 5, p = 0.23). Values represent mean ± SEM. Detailed values and statistical tests: B, Ratio of the amplitude of 16–20 EPSC to first EPSC at 50 Hz: control: 3.63 ± 0.35 vs. ZX1: 3.23 ± 0.22, n = 5, p = 0.18, F = 1.84, DFn = 1, DFd = 40; two-way ANOVA; C, ZX1–2/control1–2 vs. ZX16–20/control16–20: 1.40 ± 0.04 vs. 1.35 ± 0.05, n = 5, p = 0.23, t = 1.39, df = 4, paired t-test.