Table 3.

Factors influencing QoL in acromegaly from cross-sectional observational studies.

Reference	General factors					Disease-specific factors
	Age	Female gender	Depression	Education	BMI	Biochemical control	Hypopituitarism	GH	Disease duration	IGF1	Tumor size	Remission duration	Followup duration
Anagnostis et al. (21)	0	−−	−−	0		0	0	0a			0	0
Biermasz et al. (23)	−	0	−−				0	+	0	0		−	−
Biermasz et al. (24)	−−							+	−−
Cannavo et al. (27)								0		−−
Celik et al. (30)						0
Celik and Kadioglu (31)			−−	++		0	0
Dantas et al. (33)						+
Fathalla et al. (34)						0					0
Hatipoglu et al. (38)			−−							−−
Hatipoglu et al. (39)						0	0	0	0	0
Hua et al. (9)						0
Karaca et al. (40)						0
Kauppinen-Makelin et al. (41)	−−	0			−−		0	0, −−a		−−	++
Kepicoglu et al. (42)	0	0	−−	++		−−	0		0	++
Leon-Carrion et al. (43)			−−					++		++
Mangupli et al. (46)								0		0
Matta et al. (47)						+
Milian et al. (48)		−−		0		0							0
Miller et al. (49)									0
Postma et al. (51)	0	−−								0
Psaras et al. (52)	0	0				−				0
Psaras et al. (53)	0	0				0		0		0	0
Raappana et al. (54)						0
Rowles et al. (56)	0	0					0		0
Siegel et al. (60)										−−
T’Sjoen et al. (10)	0	−−			−−	0					0
Trepp et al. (13)						++				−−
Vandeva et al. (63)	−−	−−				0
Varewijck et al. (64)										−
Wassenaar et al. (65)	+/−						0	0, 0a	0	0		0
Yoshida et al. (67)	−−					0				−−

++ positive correlation with QoL, +positive correlation with a subscale of QoL only, −−negative correlation with QoL, −negative correlation with a subscale of QoL only, 0 no significant correlation with QoL.

^aNadir growth hormone (GH).