Table 4.
Factors influencing QoL in acromegaly in cross-sectional observational studies (previous and ongoing interventions).
| Reference | Treatment of acromegaly | Radiotherapy | Somatostatin analogs | Surgery without adjuvant treatment | Pituitary surgery | Physical activity | Use of GH-lowering medication | Number of surgeries | Surgery vs. somatostatin analogs | Lanreotide autogel after treatment with octreotide |
|---|---|---|---|---|---|---|---|---|---|---|
| Anagnostis et al. (21) | 0 | −− | ||||||||
| Biermasz et al. (23) | − | 0 | + | |||||||
| Biermasz et al. (24) | − | |||||||||
| Celik and Kadioglu (31) | ++ | |||||||||
| Dantas et al. (33) | 0 | |||||||||
| Fathalla et al. (34) | −− | −− | 0 | |||||||
| Hatipoglu et al. (39) | 0 | 0 | ||||||||
| Kauppinen-Makelin et al. (41) | −− | 0 | 0 | |||||||
| Kepicoglu et al. (42) | −− | 0 | ||||||||
| Matta et al. (47) | 0 | |||||||||
| Postma et al. (51) | 0 | |||||||||
| Raappana et al. (54) | −− | |||||||||
| Rowles et al. (56) | −− | |||||||||
| Rubeck et al. (57) | 0 | |||||||||
| Schopohl et al. (59) | 0 | |||||||||
| T’Sjoen et al. (10) | 0 | 0 | ||||||||
| Vandeva et al. (63) | −− | 0 | −− | |||||||
| Wassenaar et al. (65) | − | 0 | ||||||||
| Yoshida et al. (67) | −− | + |
++positive correlation with QoL, +positive correlation with a subscale of QoL only, −− negative correlation with QoL, −negative correlation with a subscale of QoL only, 0 no significant correlation with QoL.