Table 8.

Factors influencing QoL in patients with acromegaly (longitudinal studies^a).

Reference	General factors				Disease-specific factors
	Age	Female gender	Depression	Education	Hypopituitarism	GH	Biochemical control	Radiotherapy	Disease duration	Remission duration	IGF1	Change in IGF1
Bonapart et al. (25)						−−					0
Caron et al. (29)							0
Chin et al. (32)							−
Fujio et al. (35)	−	0					0				0
Geraedts et al. (36)			−−				0
Paisley et al. (12)								0				−−
Sardella et al. (58)							−		0
van der Klaauw et al. (62)	+/−	−−			0			−		0
Webb et al. (66)	0	−−		0	0

++positive correlation with QoL, +positive correlation with a subscale of QoL only, −−negative correlation with QoL, −negative correlation with a subscale of QoL only, 0 no significant correlation with QoL.

^aLongitudinal defined as: repeated measurements, observational.